Wellbutrin XL Extended-Release Tablets, 300 mg of bupropion hydrochloride, are creamy-white to pale yellow, round tablets printed with Wellbutrin XL 300. Contraindications Wellbutrin XL is contraindicated in patients with seizure disorder. Wellbutrin, also known by the trade name bupropion, is an antidepressant medication. The XL version is an extended-release formula and is usually taken once daily. Find patient medical information for Wellbutrin XL Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Patients who are currently being treated with WELLBUTRIN Tablets at 300 mg/day (for example, 100 mg 3 times a day) may be switched to WELLBUTRIN XL 300 mg once daily. Patients who are currently being treated with WELLBUTRIN SR Sustained-Release Tablets at 300 mg/day (for example, 150 mg twice daily) may be switched to WELLBUTRIN XL 300 mg once daily. The initial dose of Wellbutrin XL is 150 mg/day as a single dose. The target dose is 300-mg/day. Wellbutrin XL may interact with cancer medicines, heart rhythm medications, heart or blood pressure medications, other antidepressants, medicine to treat psychiatric disorders, antihistamines, asthma When people take Wellbutrin XL for seasonal affective disorder (during autumn and winter), it is recommended that they begin stopping Wellbutrin XL in early spring. The recommended dose for seasonal affective disorder is 300 mg, once daily. The dosage is typically reduced to 150 mg a day for two weeks before stopping the drug altogether. The main concern about abrupt stopping of Wellbutrin XL is a possible discontinuation syndrome. Some may experience only minor symptoms, for others, the symptoms may be so debilitating that they feel they cannot stop their antidepressant for fear of how it will interfere with their lives. Wellbutrin (bupropion) is a medication that is mainly used as a medication to help people with depression and as an aid to help people stop smoking. Was diagnosed with Chronic Fatigue. Anxiety was more of an issue than depression, but was put on Wellbutrin 150 XL because dr. had had success with it and said depression and anxiety are different sides of the same coin when I questioned being put on an antidepressant when I was anxious. The usual target dose of Wellbutrin according to the manufacturer is 300 mg per day in the form of 150 mg twice daily (with a maximum dose at 400mg per day as 200 mg twice daily); however, your specific prescription may vary. Always follow prescribed dosages.